Counseling and Explaining
The NMR LipoProfile test — The Particle Test — provides the number of LDL particles (LDL-P). This simple blood test is a management tool that provides actionable results. Knowing your patient's LDL-P, along with their LDL cholesterol (LDL-C), gives you a more complete picture to manage and maintain their heart health.
The information obtained from the NMR LipoProfile test — The Particle Test — should be used with other lipid measurements to aid in the management of cardiovascular disease. Based on your risk assessment you may determine appropriate goals for your patient.
For a complete explanation of the test results – click HERE to download.
Treatment Strategies can be found by clicking HERE.
For a patient-friendly explanation of the NMR LipoProfile test – The Particle Test – click HERE to download.
Patient-friendly tips on adopting a heart-healthy lifestyle, including diet and exercise – click HERE to download.
LDL particle number (LDL-P) can aid in determining treatment strategies and clinical decision-making for management of cardiovascular disease.
Because of variability in the amount of cholesterol carried in LDL particles, frequent discordance occurs between LDL-C and LDL-P.1 Among high cardiometabolic risk patients with LDL-C <100 mg/dL, approximately two-thirds of patients have high LDL particle concentration (LDL-P).2
Ideal candidates for measuring LDL-P are cardiometabolic risk patients whose LDL-C levels are considered to be "normal." These include patients with known cardiovascular disease, metabolic syndrome, Type 2 Diabetes, low HDL-C, obesity or a family history of heart disease.
A simple blood test, the NMR LipoProfile test — The Particle Test — is a CVD management tool with actionable results.
The following chart provides therapeutic strategies for the management of LDL-P:
THERAPIES TO ACHIEVE LDL PARTICLE NUMBER (LDL-P) TARGETS.2
|If you need to:||You should consider:|
|Lower LDL-P further||Titrate statin dosage or use more potent statin –or –statin + ezetimibe/bile acid sequestrants –or –statin + ezetimmibe + niacin|
|Any of the above + lower trigylcerides||ADD niacin, omega-3 fatty acid, fenofibrate|
|Any of the above
+ increase HDL-C
|ADD niacin, fenofibrate, omega-3 fatty acid|
If therapeutic changes are made, repeat the NMR LipoProfile test — The Particle Test — to evaluate response to therapy.
1. Otvos JD, Mora S., Shalaurova I, et al. Clinical Implications of Discordance Between LDL Cholesterol and LDL Particle Number. J.Clin Lipidology, 2011;5(2):105-113.
2. Rosenson RS et al. Underappreciated opportunities for low-density lipoprotein management in patients with cardiometabolic residual risk. Atherosclerosis 2010 Nov;213(1):1-7.